2024 SWSCC Educational Meeting - March




 A novel platform for the discovery and biotechnological production of plant endophytes as a source for cosmetic actives

Benito-Martínez, Silviaa; Perez-Aso, Miguela; Escudero Elizabetha;Akalin, Altunab; Vatsellas, Giannisc; De Vos, Ric C. H.d; Rubio, Emilioa; Bosch, Jordia; Manzano, Davida

a. Provital, Barberà del Vallès, Spain.
b. Bioinformatics & Omics Data Science platform (Berlin Institute of Medical System
Biology (BIMSB) of MDC-Berlin).
c. Greek Genome Centre, Biomedical Research Foundation of the Academy of Athens
d. BU Bioscience. Wageningen University & Research Centre.

The recent years have seen an explosion of knowledge regarding the human microbiome and its effects on health are now widely accepted. Although much less known, plants also possess their own endophytic microbiome. Endophytes are symbiotic microorganisms that live inside plants promoting
beneficial effects on their growth and development. Due to their capacity to produce a wide range of bioactive plant compounds in combination with their ability to grow under controlled conditions, plant endophytes are ideal candidates to develop a biomimicry-based strategy to identify novel
natural sources for the sustainable development of cosmetic actives.

We successfully isolated a relevant collection of endophytic strains and started a screening of bioactivities to select the best candidates for further development. Here, we provide evidence regarding the excellent cosmetic in vitro activities of the endophytic yeast Kwoniella mangroviensis. K. mangroviensis ferment extract (KMFE) exhibits a great anti-pollution effect as demonstrated in human keratinocytes exposed to urban dust. Moreover, RNA-Seq whole-transcriptome analysis shows the capacity of KMFE to induce the formation of extracellular matrix in human dermal fibroblasts, indicating a strong anti-ageing activity. Finally, to continue with the development of our pioneering biotech platform, we are currently evaluating the cosmetic properties and growth conditions of many other promising endophyte strains

Speaker Bio


Silvia Benito works as ‘Science Communication Manager’ within Provital’s R&D team in Barcelona, focusing on increasing the visibility of all the science behind the cosmetic ingredients and driving Provital’s innovation by identifying scientific trends and implementing a communication strategy.

Silvia obtained her PhD in Cell & Molecular Biology from the Research University ‘Paris Sciences et Lettres’ (PSL) in France. During her thesis and research studies she worked for 5+ years in a laboratory at the Curie Institute in Paris, investigating innovative in vitro models to address pigmentation and photoprotection in human skin. She accomplished this work collaborating with relevant partners in the cosmetic industry and thanks to several prestigious grants, such as the Marie Curie Actions provided by the European Commission, and one awarded by the French Medical Research Foundation.

Silvia has received various research awards throughout her scientific career, she won two prizes for her initial work in Spain in the ‘2017 Archimedes Competition’ at the national level, and also for her public speaking and presentation skills at the SPIM international congress of Skin Physiology, winning the ‘2020 Junior Scientist’ award for best talk in the Dermatology and Cosmetics worlds.

Now, she lives in Barcelona, enjoying the Mediterranean lifestyle and her new dream job at Provital by combining her two passions: science and communication

Event Properties

Event Date March 21, 2024
Event End Date March 21, 2024
Cut off date March 22, 2024
Capacity 60
Available place 22
Location Hampton Inn Houston Downtown

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